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This is great news, especially for people with GT3 and cirrhosis. Remember to help us get Maviret (Mavyret in Canada) covered by BC PharmaCare by filling in the Patient Input questionnaire found here.
Glecaprevir and pibrentasvir, the two drugs in the recently approved Maviret co-formulation, demonstrated high sustained response rates for people with chronic hepatitis C virus (HCV) genotype 3 and for people with liver cirrhosis, according to a pair of reports presented at the 2017 AASLD Liver Meeting this week in Washington, DC.
An integrated analysis of clinical trial data showed that glecaprevir/pibrentasvir taken for 8 weeks cured 98% of people without cirrhosis with hard-to-treat genotype 3, while a 12-week course cured 100% of people with genotype 3 with cirrhosis. A related analysis showed that the combination taken for 12 or 16 weeks cured 96% of people with compensated cirrhosis across all genotypes.
“This integrated analysis supports the high efficacy and favourable safety profile of glecaprevir/pibrentasvir in patients with HCV genotypes 1-6 infection and compensated cirrhosis,” the researchers concluded.