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A combination of two experimental direct-acting antivirals developed by AbbVie cured 97%-100% of non-cirrhotic people with genotype 1 hepatitis C infection in a mid-stage phase 2 study presented this week at the AASLD Liver Meeting in San Francisco.
The SURVEYOR-1 study assessed the effectiveness and safety of two experimental next-generation direct-acting antivirals. ABT-493 is an HCV NS3/4A protease inhibitor active against all genotypes of hepatitis C. ABT-530 is a NS5A inhibitor also active against all genotypes of HCV. Both agents are active against common variants that confer resistance to first-generation agents of their classes. ABT-493 is more potent against genotype 3 than other HCV protease inhibitors, including products being developed by Merck (grazoprevir) and Gilead (GS-9451), and ABT-530 has demonstrated higher potency than most other NS5A inhibitors across all genotypes.
The new experimental combination is not only active across all genotypes, but does not need ritonavir boosting to maintain adequate levels of its protease inhibitor component. This minimises the potential for drug-drug interactions, which are a concern with any ritonavir-containing treatment due to the agent’s interaction with a wide range of medications metabolised through the p450 CYP3A4 liver enzyme pathway.
The study compared two doses of ABT-530 (40 or 120mg) combined with 200mg of ABT-493, both dosed orally once a day, for 12 weeks.
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